Proefschrift

CHAPTER 1. INTRODUCTION Contents 1.1 Brief History of Prostate Cancer and Its Treatment . . . . . . 3 1.2 The Cause of Treatment Failure . . . . . . . . . . . . . . . . . . 5 1.3 The Folly of Maximum Tolerated Dose . . . . . . . . . . . . . . 6 1.4 A Similar “Resistance Crisis” . . . . . . . . . . . . . . . . . . . . 8 1.5 Integrated Metastatic Management . . . . . . . . . . . . . . . . 9 1.6 Adaptive Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1.7 Mathematical Modeling as a Bridge . . . . . . . . . . . . . . . . 11 1.8 Evolutionary Game Theory of mCRPC . . . . . . . . . . . . . . 13 1.9 Optimal Control of mCRPC . . . . . . . . . . . . . . . . . . . . . 13 1.10 Thesis Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 1.11 Reading Guidelines . . . . . . . . . . . . . . . . . . . . . . . . . . 15 1.12 Associated Publications of Thesis Chapters . . . . . . . . . . . . 16 2