Proefschrift

Langstaff, G. (1817). Cases of fungus haematodes, with observations. 4 Lankau, R. (2011). Rapid evolutionary change and the coexistence of species. Annual Review of Ecology, Evolution, and Systematics , 42(1):335–354. 98 Le Tourneau, C., Lee, J., and Siu, L. (2009). Dose Escalation Methods in Phase I Cancer Clinical Trials. JNCI: Journal of the National Cancer Institute , 101(10):708–720. 7 Ledzewicz, U., Naghnaeian, M., and Sch attler, H. (2012). Optimal response to chemotherapy for a mathematical model of tumor-immune dynamics. Journal of Mathematical Biology , 64(3):557–577. 14, 64 Ledzewicz, U. and Sch¨attler, H. (2005). The influence of PK/PD on the structure of optimal controls in cancer chemotherapy models. Mathematical Biosciences & Engineering , 2(3):561–578. 14, 64 Ledzewicz, U. and Sch¨attler, H. (2008). Optimal and suboptimal protocols for a class of mathematical models of tumor anti-angiogenesis. Journal of Theoretical Biology , 252(2):295–312. 14, 64 Ledzewicz, U. and Sch¨attler, H. (2016). Optimizing chemotherapeutic anti-cancer treatment and the tumor microenvironment: An analysis of mathematical models. Advances in Experimental Medicine and Biology , 936:209–223. 14, 64 Leung, C. and Weitz, J. (2017). Modeling the synergistic elimination of bacteria by phage and the innate immune system. Journal of Theoretical Biology , 429:241–252. 97 Liang, Y., Leung, K., and Mok, T. (2006). A novel evolutionary drug scheduling model in cancer chemotherapy. IEEE Transactions on Information Technology in Biomedicine , 10(2):237–245. 76 Lilja, H., Ulmert, D., and Vickers, A. (2008). Prostate-specific antigen and prostate cancer: prediction, detection and monitoring. Nature Reviews Cancer , 8(4):268–278. 31 Lloyd, M., Cunningham, J., Bui, M., Gillies, R., Brown, J., and Gatenby, R. (2016). Darwinian dynamics of intratumoral heterogeneity: not solely random mutations but also variable environmental selection forces. Cancer Research , 76(11):3136–3144. 49 Lobato, F., Machado, V., and Steffen Jr., V. (2016). Determination of an optimal control strategy for drug administration in tumor treatment using multi-objective optimization differential evolution. Computer Methods and Programs in Biomedicine , 131:51–61. 76 Lotka, A. J. (2002). Contribution to the theory of periodic reactions. The Journal of Physical Chemistry , 14(3):271–274. 3 Maley, C., Reid, B., and Forrest, S. (2004). Cancer prevention strategies that address the evolutionary dynamics of neoplastic cells: simulating benign cell boosters and selection for chemosensitivity. Cancer Epidemiology and Prevention Biomarkers , 13(8):1375–1384. 11 178