Proefschrift

Supervisors: Prof. dr. F. Thuijsman Prof. dr. ir. R.L.M. Peeters Dr. K. Stanˇkov´a Assessment Committee: Prof. dr. G.B. Weiss (chairman) Prof. dr. ir. I.C.W. Arts Dr. W. Huang, Queen Mary University of London Prof. dr. P. Lambin Dr. J.G. Scott, Case Western Reserve University The research reported in this thesis was financial ly supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 690817, the Dutch National Foundation (NWO) Visitor’s Travel Grant number 040.11.712, the James S. McDonnel l Foundation grant, Cancer therapy: Perturbing a complex adaptive system, a V Foundation grant, NIH/NCI R01CA170595, Application of Evolutionary Principles to Maintain Cancer Control (PQ21), NIH/NCI U54CA143970-05 Physical Science Oncology Network (PSON) Cancer as a complex adaptive system, and the Department of Data Science and Knowledge Engineering, Maastricht University. © Jessica J. Cunningham, 2021 ISBN 978-94-6419-313-8 Cover art and design © Leslie Caroline Wilcox, 2021 Printed by: Gildeprint