Proefschrift

Contents 1 Introduction 1 2 A Call for Integrated Metastatic Management 17 3 Game Theoretic Model of Metastatic Castrate-Resistant Prostate Cancer and Abiraterone 25 4 Integrating Evolutionary Dynamics into Treatment of Metastatic Castrate-Resistant Prostate Cancer 47 5 Optimal Control to Develop Therapeutic Strategies for Metastatic Castrate-Resistant Prostate Cancer 61 6 Optimal Control to Reach Eco-Evolutionary Stability in Metastatic Castrate-Resistant Prostate Cancer 79 7 Discussion 101 8 Summary 117 9 Impact 121 A Supplement to Chapter 5 125 B Supplement to Chapter 6 137 Acknowledgements 155 About the Author 159 Bibliography 165 iii