refusal. In response to these challenges, a better understanding of ‘treatment fatigue’ might result in better care for patients with treatment resistant psychiatric disorders, may yield a better understanding of treatment refusal, and may eventually lead to subsidiary alternatives to PAD. Finally, by drafting clinical criteria for IPS in the context of PAD through a process of consensus formation, many of the identified challenges can be mitigated. A QUALITATIVE STUDY ON IRREMEDIABILITY | 89 5