Proefschrift

Chapter 8 110 Table 8.2 Outcomes base case and sensitivity analysis scenarios. PWB (N=53) RWB (N=53) p FMe FU W6 FU W12 FU W26 FM e FU W6 FU W12 FU W26 PWB RWB LEFS (SD) Total LEFS-scores in patients with paid job 22.15 (12.15) 43.00 b (13.71) 54.07 (13.17) 65.81 (13.03) 9.96 (5.11) 15.07 (6.97) 29.48 (14.59) 52.96 (11,41) <0.01f,g <0.01f,g Total LEFS-Scores in patients without paid job 18.35 (9.63) 34.46 b (10.21) 51.58 (11.45) 57.46 (9,67) 10.92 (3.54) 17.54 (5.14) 35.54 (9.82) 46.26 (14.04) <0.01f,g <0.01f,g Total LEFS-scores 20.28 a (11.05) 38.8 a (12.75) 52.85 a (12.30) 61.53 (12.02) 10.43 a (4.40) 16.28 a (6.21) 32.45 a (12.73) 49.54 (13.14) <0.01f,g <0.01f,g,h Utility scores (SD) Utility scores in patients with paid job 0.49 (0.22) 0.73 (0.13) 0.82 (0.10) 0.89 (0.15) 0.32 (0.13) 0.40 (0.10) 0.67 b (0.15) 0.80 b (0.068) < 0.01g < 0.01g Utility scores in patients without paid job 0.38 (0.24) 0.70 (0.16) 0.80 (0.13) 0.81 (0.17) 0.25 (0.19) 0.32 (0.24) 0.52 b (0.26) 0.68 b (0.29) 0.01 Total Utility scores 0.44 a (0.23) 0.72 a (0.14) 0.81 a (0.11) 0.85 a (0.16) 0.28 a (0.16) 0.36 a (0.19) 0.59 a (0.22) 0.74 a (0.22) <0.01 QALY (SD) Total QALY in patients with paid job 0.018 (0.017) 0.06 (0.043) 0.017 (0.027) 0.006 (0.010) 0.07 (0.035) 0.035 (0.036) <0.01f <0.01f Total QALY in patients without paid job 0.025 (0.016) 0.081 (0.049) 0.003 (0.05) 0.006 (0.017) 0.05 (0.051) 0.045 (0.080) Total QALY c, d 0.021 a (0.017) 0.072 a (0.047) 0.01 (0.04) 0.006 a (0.139) 0.059 a (0.045) 0.040 (0.062) a Sig. difference between PWB and RWB at 5% level; b Sig. Difference in group between patients with paid job and patients without paid job at 5% level; c Total QALYs are calculated over 12 weeks (max. QALY is 0.23); d QALY calculated according to NL-tariff); e First Measurements were conducted 2 weeks after initial injury; f Between FM and FU W6; g Between FU W6 and FU W12; h Between FU W12 and FU W26. Abbreviation: PWB, permissive weight bearing; RWB, restricted weight bearing; N, number of subjects; SD, standard deviation; FM, First measurement; FU, follow-up; W, week; LEFS, lower extremity functional scale; QALY, quality adjusted life year.

RkJQdWJsaXNoZXIy MjY0ODMw