Proefschrift

Chapter 1 10 may lead to a host of problems such as loss of function, loss of muscle strength, loss of connective tissue’s loading capacity, persistent edema, osteoporosis due to inactivity, and loss of joint mobility.15,16 Over-loading is considered to increase the frequency of failure of osteosynthesis with mal-union and non-union. To clinically optimize fast recovery and advance restoration of function and functionality, one may want to set out a treatment that is near to the upper boundary of the therapeutic bandwidth, yet safe enough to avoid overloading. Also from a viewpoint of physiologic complexity and ageing, early recovery/rehabilitation is essential to ensure optimal outcome.17,18 Figure 1.1 Schematic overview of the consequences of loading on the fracture consolidation process. Clinicians prescribe non-weight bearing or partial weight bearing (restricted weight bearing (RWB) regimens) as standard treatment for peri-articular or intraarticular lower extremity fractures in an attempt to create an optimal protective mechanical environment at the different stages of healing. This strategy varies, based on the type of fracture, extent of the injury, and the preferences of the treating

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