5 147 Neural signatures of parental empathic responses to imagined suffering of their adolescent child SUPPLEMENT S5.4 Peak activation coordinates at whole-brain level for main effects of ‘perspective’ and ‘stimulus type’ and their interaction Brain regions MNI-coordinates Voxel test value Cluster p-value Cluster size x y z Z Main effect ‘perspective’ L Precuneus -3 -56 30 ≥8 <.001 13395 R Inferior parietal gyrus 47 -54 41 6.51 R Precuneus 5 -68 41 6.22 L Superior frontal gyrus, ventromedial -6 54 -8 7.24 <.001 5209 L Superior frontal gyrus, medial -5 54 20 4.78 L Superior frontal gyrus, dorsolateral -11 51 35 4.16 R Inferior temporal gyrus 45 -63 -12 6.45 <.001 12268 R Inferior occipital gyrus 41 -71 -11 6.07 R Middle occipital gyrus 41 -84 0 6.01 L Inferior occipital gyrus -44 -83 -9 6.10 <.001 5575 L Middle occipital gyrus -39 -89 -6 5.83 L Middle occipital gyrus -38 -90 5 5.22 R Superior frontal gyrus, dorsolateral 27 3 60 5.70 <.001 2139 R Middle frontal gyrus 35 9 54 5.24 R Middle frontal gyrus 44 15 45 4.13 R Middle frontal gyrus 47 39 21 4.84 .003 861 R Middle frontal gyrus 33 50 35 3.48 R Middle frontal gyrus 36 50 26 3.32 R Inferior frontal gyrus, orbital part 44 45 -6 4.59 .012 662 L Inferior frontal gyrus, triangular part -60 18 29 4.40 <.001 1624 L Precentral gyrus -42 5 39 4.19 L Precentral gyrus -45 -6 60 3.91 Main effect ‘stimulus type’ L Inferior frontal gyrus, triangular part -48 39 11 < 8 <.001 5755 L Middle frontal gyrus -26 27 53 3.98 L Middle frontal gyrus -45 53 -9 3.92 L Middle frontal gyrus -32 39 -12 < 8 .002 1039 L Inferior temporal gyrus -59 -54 -9 6.78 <.001 3861 L Inferior temporal gyrus -57 -47 -15 6.70 L Inferior temporal gyrus -50 -54 -20 5.78
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