5 151 Neural signatures of parental empathic responses to imagined suffering of their adolescent child SUPPLEMENT S5.7 Brain results at region of interest and whole-brain level for the interaction between ‘perspective’ and ‘stimulus type’ A) Significant interactions between ‘perspective’ and ‘stimulus type’ at ROI level were found in aMCC (p = .003) and vmPFC (p <.001). B) Significant interactions between ‘perspective’ and ‘stimulus type’ at wholebrain level revealed significant clusters of activity in left insula (p = .013), and right dmPFC (p <.001). Although we did not find a significant BOLD-response in the ROI of the left AI (blue sphere) for the interaction between ‘perspective’ and ‘stimulus type’, we did find a significant cluster at whole-brain level in the left insula, which is clarified in the figure by the lack of overlap between the whole-brain activation cluster and the ROI sphere of the left AI. Error bars represent standard error of the mean. Significant p-values <.05 were indicated by *, p <.01 by **, and p <.001 by ***.
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