Proefschrift

3.1 Sex differences in generalizability of HFrEF trials 105 SUPPLEMENTARY MATERIAL Supplementary table1. See Supplementary table 1 of Chapter 2.1 Supplementary table 2. Baseline characteristics of total registry population, RCT-eligible and RCT-ineligible stratified by sex Total Registries RCT-Eligible RCT-non-eligible Females Males Females Males Females Males n 14 584 32 338 8 294 17 810 6 290 14 520 Demographics and lifestyle, mean (SD) or % Age (years) 75.1 (9.4) 71.6 (15.3) 73.9 (9.1) 69.8 (12.2) 76.7 (9.7) 73.8 (9.3) Smoking history Never 54.7% (6727) 36.5% (10203) 53.0% (3793) 35.5% (5569) 57.2% (2934) 37.8% (4634) Previous/Current 45.3% (5569) 63.5% (17731) 47.0% (3370) 64.5% (10116) 42.8% (2199) 62.2% (7615) Clinical parameters, mean (SD) or % HF duration (months) 21.1 (47.3) 27.9 (66.6) 21.0 (58.6) 30.8 (58.8) 21.1 (32.2) 24.4 (31.2) SBP (mmHg) 126.1 (16.5) 123.9 (25.5) 126.4 (16.0) 123.7 (20.5) 125.7 (17.1) 124.0 (15.2) DBP (mmHg) 72.3 (11.8) 73.4 (15.8) 72.8 (12.9) 74.2 (12.3) 71.7 (10.6) 72.5 (9.9) BMI (kg/m2) 26.2 (5.7) 26.7 (7.4) 26.6 (6.5) 27.2 (6.0) 25.6 (4.7) 26.0 (4.3) *Haemoglobin (g/dL) 12.8 (1.2) 13.6 (2.5) 13.1 (1.1) 14.0 (2.1) 12.6 (1.3) 13.0 (1.5) *Creatinine (μmol/L) 98.5 (26.6) 115.2 (71.6) 90.6 (37.6) 103.4 (38.2) 108.9 (0.3) 129.7 (60.6) LVEF (count, %) 0-29 45.4% (6627) 52.8% (17060) 47.5% (3939) 56.1% (9997) 42.7% (2688) 48.6% (7063) 30-39 54.6% (7957) 47.2% (15270) 52.5% (4355) 43.9% (7813) 57.3% (3602) 51.4% (7457)

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