3.1 Sex differences in generalizability of HFrEF trials 107 Supplementary table 2 (continued). Baseline characteristics of total registry population, RCT-eligible and RCT-ineligible stratified by sex Total Registries RCT-Eligible RCT-non-eligible Females Males Females Males Females Males *Haemoglobin (g/dL) <8.0 0.1% (21) 0.1% (39) 0.0% (0) 0.0% (0) 0.3% (21) 0.3% (39) 8.0-10.9 12.0% (1754) 8.1% (2624) 7.5% (624) 0.0% (0) 18.0% (1130) 18.1% (2624) 11.0-12.9 40.8% (5949) 27.1% (8772) 41.0% (3400) 25.9% (4607) 40.5% (2549) 28.7% (4165) 13.0 - 14.9 37.8% (5507) 42.2% (13659) 41.0% (3401) 47.6% (8479) 33.5% (2106) 35.7% (5180) 15.0 - 16.9 8.7% (1268) 20.4% (6580) 9.8% (813) 24.1% (4301) 7.2% (455) 15.7% (2279) 17.0 and above 0.6% (85) 2.0% (656) 0.7% (56) 2.4% (423) 0.5% (29) 1.6% (233) Comorbidities % Hypertension 58.0% (8465) 54.7% (17689) 59.1% (4904) 54.7% (9741) 56.6% (3561) 54.7% (7948) Diabetes mellitus 25.7% (3755) 27.8% (8989) 25.8% (2137) 27.8% (4954) 25.7% (1618) 27.8% (4035) Previous MI 29.7% (4328) 32.7% (10570) 30.0% (2489) 31.6% (5633) 29.2% (1839) 34.0% (4937) CAD 48.6% (5981) 52.2% (15687) 49.0% (3513) 48.6% (8661) 48.1% (2468) 57.4% (7026) Valvular heart disease 25.2% (3672) 22.3% (7222) 24.2% (2008) 20.2% (3599) 26.5% (1664) 25.0% (3623) Stroke or TIA 15.2% (1874) 15.8% (4413) 14.3% (1021) 14.0% (2201) 16.6% (853) 18.1% (2212) Atrial fibrillation/flutter 44.4% (5957) 50.1% (15047) 42.2% (3501) 46.7% (8318) 47.8% (2456) 54.9% (6729) COPD 21.6% (3157) 19.6% (6344) 21.3% (1765) 18.6% (3313) 22.1% (1392) 20.9% (3031) Depression 6.3% (777) 4.4% (1230) 6.2% (445) 4.3% (670) 6.5% (332) 4.6% (560) *Cancer 27.4% (2035) 28.1% (4681) 0.0% (0) 0.0% (0) 32.4% (2035) 32.2% (4681)
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