3.1 Sex differences in generalizability of HFrEF trials 111 Supplementary figure 2. Sensitivity analysis for CV and all-cause SMRs for females in the total population, CAD subpopulation, and SR subpopulation. Standardized mortality ratios for all-cause mortality and CV-cause mortality within one-year for females. SMRs calculated for females in the total population, those only in SR, and those only with CAD. HF prognostic factors from the MAGGIC risk model were added stepwise to each model until the fully adjusted model 4. The models were applied to the RCT-eligible population and the derived coefficients were then applied to the RCT population to predict expected deaths. SMRs were calculated by dividing observed RCT deaths by expected RCT deaths. Pooled SMRs estimated from five trials with their 95% CI were reported. Similar results were found in all populations, however the risk difference between the RCT and RCT-eligible population was even larger in the CAD subpopulation. Abbreviations as seen in Table 1.
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