3.1 Sex differences in generalizability of HFrEF trials 113 Supplementary Table 4. Baseline characteristics of contemporary HFrEF trials compared to RCT population in study. PARADIGM-HF ATMOSPHERE COMMANDER- HF DAPAHF VICTORIA EMPEROR- REDUCED RCTs (combined) (N=8442) (N=7063) (N=5022) (N=4744) (N=5 050) Treatment: 1863/Placebo: 1867 (n = 16 922) Age (years) 64 63 66 66 67 67/66 64 Female sex – no. (%) 22 22 23 23 23 24/24 22 Clinical parameters, mean or % NYHA class, % I 5 2 3 0 0 - 0 II 70 69 44 68 59 75/75 61 III 24 28 49 32 40 24/24 38 IV 1 1 4 1 1 0/1 1 LVEF, % 29 28 34 31 29 27/27 31 NT-proBNP, pg.ml All 1615 1198 - 1437 3377 1887/1926 2036* No AF/F 1444 1014 2850 1291 - - - AF/F 1955 1652 - 1945 - - - History of HF hospitalization, % 63 60 100+ 47 84 31 - Ischaemic aetiology, % 60 56 100 56 - 53/50 69 Blood pressure - mmHg Systolic 121 124 - 122 121 123/121 125 Diastolic 74 75 - 74 73 - 76
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