CHAPTER 3.1 114 Supplementary Table 4 (continued). Baseline characteristics of contemporary HFrEF trials compared to RCT population in study. PARADIGM-HF ATMOSPHERE COMMANDER- HF DAPAHF VICTORIA EMPEROR- REDUCED RCTs (combined) (N=8442) (N=7063) (N=5022) (N=4744) (N=5 050) Treatment: 1863/Placebo: 1867 (n = 16 922) Heart rate 72 72 - 72 73 71/72 74 eGFR 68 74 - 66 62 62/62 - Creatinine 99 92 - 99 106* - 99 Haemoglobin, g/L 140 138 - 136 134 - 140 Anaemia, % All - - - - 21 - 3 Males 21 22 - 28 - - 3 Females 18 24 - 26 - - 6 Smoking (current), % - - - 14 - - 16 Comorbidities (%) BMI, kg/m2 28 27 28 27 27* 28/28 28 Obese, % 32 27 29 35 - - 32 Diabetes, % 34 28 41 42 47 50/50 34 Hypertension, % 71 62 75 74 79 72/72 68 MI, % 43 41 76 44 - - 34 PCI, % 21 20 - 34 - - 9 CABG, % 15 14 - 17 - - 6 Stroke, % 9 7 9 10 12 9 Atrial fibrillation, % 37 34 0 40 45 36/38 32
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