3.1 Sex differences in generalizability of HFrEF trials 115 Supplementary Table 4 (continued). Baseline characteristics of contemporary HFrEF trials compared to RCT population in study. PARADIGM-HF ATMOSPHERE COMMANDER- HF DAPAHF VICTORIA EMPEROR- REDUCED RCTs (combined) (N=8442) (N=7063) (N=5022) (N=4744) (N=5 050) Treatment: 1863/Placebo: 1867 (n = 16 922) CAD, % - - 100 - 58 - COPD, % 17 - Concomitant medications (%) Diuretic 80 80 100 93 - - 72 ACEi 78 100 72 56 - - ARB 23 0 22 28 - - ACEi or ARB 100 100 93 94* 74 - 90 Β-blocker 93 92 92 96 93 95/95 88 MRA 60 37 77 71 70 70/73 Digitalis glycoside 30 32 9 19 - - 15 Ivabradine 2 1 - 5 - - - CRT 7 6 2 7 - 12/12 - ICD 15 15 9 26 28 31/32 - *Limited data availability
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