21 Generalizability of HFrEF trials Figure 1. Flow chart of selection of RCT-eligible patients based on harmonised eligibility criteria CHECK-HF registry (2013-2016) 6684 (100%) RCT-eligible 3256 (49%) RCT-non-eligible 3428 (51%) Inclusion criteria: Number (%) which did not fulfil inclusion criteria Age >=18 0 (0%) NYHA class II-IV 992 (15%) B-blocker -yes 976 (15%) ACEI/ARB- yes 876 (13%) Exclusion criteria : Number(%) Creatinine >220 µmol/L 276 (4%) Haemoglobin <11 g/dL (men) or <10g/dL (women) 660 (10%) Cancer 902 (13%) SwedeHF registry (2000-2016) 40 230 (100%) RCT-eligible 22 848 (57%) RCT-non-eligible 17 382 (43%) Inclusion criteria: Number (%) which did not fulfil inclusion criteria Age >=18 5 (0.0001%) NYHA class II-IV 3475 (9%) B-blocker -yes 4437 (11%) ACEI/ARB- yes 5162 (13%) Exclusion criteria : Number(%) Liver disease 957 (2%) Creatinine >220 µmol/L 1478 (4%) Haemoglobin <11 g/dL (men) or <10g/dL (women) 2522 (6%) Cancer 5808 (14%) Percentages of those not included and excluded based on individual criteria does not add up to percentage of non-eligible patients because one patient can be excluded based on one or more criteria Liver disease status was not recorded in CHECK-HF 2.1
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