CHAPTER 2.1 22 Table 1. Characteristics of HFrEF patients by RCT and registry groups Registry population RCT vs RCT-eligible RCT population N= 16 922 RCT- eligible N= 26 104 (56%) RCT-noneligible N=20 810 (44%) Difference in mean or proportion (99% CI) p-value b Patient characteristics Age (years) 63.6 ± 10.0 71.1 ± 12.6 74.7 ± 13.1 -7.5 (-7.8, -7.2) *** Women 3663 (22%) 8294 (32%) 6290 (30%) -10.1% (-11.2%, -9.0%) *** Body mass index (kg/m2) 28.3 ± 4.4 27.1 ± 5.7 25.9 ± 6.1 -1.2 (-1.3, -1.1) *** Systolic blood pressure – mmHg 125.2 ± 13.4 124.6 ± 21.0 124.5 ± 22.7 0.6 (0.1, 1.1) *** Diastolic blood pressure – mmHg 76.6 ± 8.4 73.7 ± 12.3 72.3 ± 13.4 2.9 (2.6, 3.2) *** Heart rate – beats per minute 74.4 ± 9.5 74.5 ± 15.9 75.7 ± 17.4 -0.1 (-0.4, 0.2) Serum creatinine - μmol/L 99.2 ± 29.5 99.4 ± 37.9 123.4 ± 91.2 -0.2 (-1.1, 0.6) Haemoglobin -g/dL 14.1 ± 1.3 13.7 ± 2.1 12.9 ± 2.6 0.4 (0.4, 0.4) *** Current smoker 2667 (16%) 3370 (15%) a 2301 (13%) a 1.1% (0.1%, 2.0%) ** Heart failure severity Duration of heart failure -months 42.0 ± 56.4 29.8 ± 61.7 32.9 ± 61.9 12.2 (10.7, 13.7) *** LVEF categories-no (%) <30 5338 (32%) 13 936 (53%) 9751 (47%) - *** 30-39 11 225 (66%) 12 168 (47%) 11 059 (53%) >=40 247 (1%) - - missing 112(1%) - - Mean LVEF (%) 31 - - -
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