Generalizability of HFrEF trials 25 Central illustration. Cumulative incidence and case-mix adjusted standardised mortality ratios for all-cause and cardiovascular mortality at one year. (A) Cumulative incidence for allcause mortality between RCT and registry patients. (B) Cumulative incidence for cardiovascular mortality between RCT and registry patients. (C) Standardised mortality ratios (SMR) for allcause and cardiovascular mortality with stepwise adjustment for HF prognostic factors. Pooled SMRs estimated from 5 trials with their 95% CI were reported. ϱϲй ĞůŝŐŝďůĞ Z d ZĞŐŝƐƚƌLJ ůŝŐŝďůĞ EŽŶͲĞůŝŐŝďůĞ KůĚĞƌ͕ ŵŽƌĞ ǁŽŵĞŶ ,ŝŐŚĞƌ >s & >ŽǁĞƌ >s & DŽƌĞ ŶŽŶͲĐĂƌĚŝĂĐ ĐŽŵŽƌďŝĚŝƚŝĞƐ ĂƐĞůŝŶĞ ĚŝĨĨĞƌĞŶĐĞƐ ďĞLJŽŶĚ ĞůŝŐŝďŝůŝƚLJ ĐƌŝƚĞƌŝĂ ƉƉůLJ ŚĂƌŵŽŶŝƐĞĚ ĞůŝŐŝďŝůŝƚLJ ĐƌŝƚĞƌŝĂ ZĞĂů ǁŽƌůĚ ,& ƉŽƉƵůĂƚŝŽŶ ; Ϳ KŶĞͲLJĞĂƌ ĂůůͲĐĂƵƐĞ ŵŽƌƚĂůŝƚLJ ; Ϳ KŶĞͲLJĞĂƌ ĐĂƌĚŝŽǀĂƐĐƵůĂƌ ŵŽƌƚĂůŝƚLJ Number at risk Registry (RCT-non-eligible) 17382 14739 13649 12693 11886 Registry (RCT-eligible) 22848 21437 20518 19609 18713 RCT 16922 16605 16324 15624 14993 Number at risk Registry (RCT-non-eligible) 17382 14740 13651 12697 11888 Registry (RCT-eligible) 22848 21436 20516 19607 18711 RCT 16922 16605 16324 15624 14993 DŽĚĞů ϰ ;ŵŽĚĞů ϯ н ƐŵŽŬŝŶŐ ƐƚĂƚƵƐ͕ D/͕ ,& ĚƵƌĂƚŝŽŶ͕ >s &͕ KW ͕ ĚŝĂďĞƚĞƐͿ DŽĚĞů ϯ ;ŵŽĚĞů Ϯ н Ez, ͕ ^ W͕ ĐƌĞĂƚŝŶŝŶĞͿ DŽĚĞů Ϯ ;ĂĚũƵƐƚĞĚ ĨŽƌ ĂŐĞ͕ ƐĞdžͿ DŽĚĞů ϭ ;ƵŶĂĚũƵƐƚĞĚͿ ĂƌĚŝŽǀĂƐĐƵůĂƌ ŵŽƌƚĂůŝƚLJ DŽĚĞů ϰ ;ŵŽĚĞů ϯ нƐŵŽŬŝŶŐ ƐƚĂƚƵƐ͕ D/͕ ,& ĚƵƌĂƚŝŽŶ͕ >s &͕ KW ͕ ĚŝĂďĞƚĞƐͿ DŽĚĞů ϯ ;ŵŽĚĞů Ϯ нEz, ͕ ^ W͕ ĐƌĞĂƚŝŶŝŶĞͿ DŽĚĞů Ϯ ;ĂĚũƵƐƚĞĚ ĨŽƌ ĂŐĞ͕ ƐĞdžͿ DŽĚĞů ϭ ;ƵŶĂĚũƵƐƚĞĚͿ ůůͲĐĂƵƐĞ ŵŽƌƚĂůŝƚLJ ϭ͘Ϯϴ ϭ͘Ϯ͕ ϭ͘ϯϳ ϭ͘Ϯϰ ϭ͘ϭϳ͕ ϭ͘ϯϯ ϭ͘ϭϵ ϭ͘ϭϮ͕ ϭ͘Ϯϳ Ϭ͘ϲϮ Ϭ͘ϱϴ͕ Ϭ͘ϲϲ ϭ͘Ϭϰ Ϭ͘ϵϴ͕ ϭ͘ϭϭ ϭ͘Ϭϭ Ϭ͘ϵϱ͕ ϭ͘Ϭϴ Ϭ͘ϵϳ Ϭ͘ϵϮ͕ ϭ͘Ϭϯ Ϭ͘ϱϮ Ϭ͘ϰϵ͕ Ϭ͘ϱϲ ^DZ ϵϱй / Ϭ͘Ϯϱ Ϭ͘ϱ ϭ Ϯ Lower risk in Z d <--- ---> Higher risk in RCT (C) Standardised mortality ratios (RCT vs RCT-eligible registry patients) 2.1
RkJQdWJsaXNoZXIy MjY0ODMw