Generalizability of HFrEF trials 39 Supplementary table 1 (continued). Characteristics, inclusion and exclusion criteria of trials Study name BEAUTIFUL CONFIRM-HF FAIR-HF PANTHEON SHIFT Clinically relevant permanent or intermittent atrioventricular-block > grade II in patients without a permanent pacemaker or ICD / CRTD Known clinically relevant ventricular arrhythmias (sustained ventricular tachycardia, ventricular flutter or fibrillation) within 3 months prior to consent based on either medical history or implantable cardioverter defibrillator Severe valvular disease with indicated or planned valve repair / anticipated heart transplantation and / or implantation of a ventricular assist device Cardiac resynchronisation therapy started within the previous 6 months Pacemaker with atrial or ventricular pacing (except bi-ventricular pacing) > 40 % of the time, or with a stimulation threshold at the atrial or ventricular level ≥ 60 bpm Permanent atrial fibrillation or flutter Sick sinus syndrome, sinoatrial block, 2nd and 3rd degree atrio-ventricular block History of symptomatic or sustained (≥ 30 sec) ventricular arrhythmia unless a cardioverter defibrillator was implanted Any cardio defibrillator shock experienced within the previous 6 months. Familial history or congenital long QT syndrome or treated with selected QT prolonging products Previous cardiac transplantation or on list for cardiac transplantation 2.1
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