CHAPTER 2.1 42 Supplementary table 1 (continued). Characteristics, inclusion and exclusion criteria of trials Study name BEAUTIFUL CONFIRM-HF FAIR-HF PANTHEON SHIFT Sustained systolic blood pressure ≤ 90 mmHg and / or signs and symptoms of hypotension prior to randomization Severe or uncontrolled hypertension at the time of selection (SBP > 180 mmHg or DBP > 110 mmHg) Sustained systolic blood pressure ≥ 160 mmHg Severe or uncontrolled hypertension (sitting SBP > 180 mmHg or sitting DBP > 110 mmHg) Sitting SBP < 85 mm Hg or current symptomatic hypotension Sustained bradycardia with heart rate < 50 beats/minute or tachycardia with heart rate > 100 beats/minute prior to randomization Severe pulmonary disease with any of the following: - Requirement of continuous (home) oxygen or - History of chronic obstructive pulmonary disease ≥ GOLD III or - Bronchial asthma
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