Generalizability of HFrEF trials 47 Supplementary table 3. Baseline characteristics by registry CHECK-HF SwedeHF Patient characteristics Age (years) 71.8 ±12.2 72.8 ±12.9 Women 2289 (34%) 12296 (31%) Body Mass Index (kg/m2) 27.2 ±5.4 26.4 ±6.7 Systolic blood pressure – mmHg 124.4 ±21.1 124.6 ±22 Diastolic blood pressure – mmHg 71.1 ±11.6 73.4 ±13.3 Heart rate – beats per minute 71.9 ±14.4 75.6 ±18.1 Serum creatinine -μmol/L 111 ±73.4 109.9 ±64 Haemoglobin -g/dL 13 ±3.5 13.4 ±1.8 Current smoker - 5671 (14%) Heart failure aetiology & severity Duration of heart failure (months) 60.5 ±74.1 26.3 ±45.8 LVEF categories-no (%) <30 3647 (55%) 20040 (50%) 30-39 3037 (45%) 20190 (50%) NYHA Functional Class – no (%) I 992 (15%) 3467 (9%) II 3847 (58%) 17862 (44%) III 1722 (26%) 16573 (41%) IV 123 (2%) 2328 (6%) Medical history – no (%) Hypertension 2579 (39%) 23580 (59%) Diabetes mellitus 1943 (29%) 10789 (27%) Coronary artery disease - 21413 (53%) History of MI 2156 (32%) 12740 (32%) Valvular disease 960 (14%) 9936 (25%) Stroke/ TIA - 6287 (16%) Anaemia 2701 (40%) 12974 (32%) COPD 1210 (18%) 8291 (21%) Depression - 2011 (5%) Cancer 902 (13%) 5808 (14%) Coronary revascularisation PCI 1363 (20%) 2159 (5%) CABG 1127 (17%) 4520 (11%) PCI + CABG 311 (5%) 4622 (11%) 2.1
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