CHAPTER 2.1 50 Supplementary figure 1. Standardised mortality ratios (SMR) for all-cause mortality with stepwise addition of HF prognostic factors for (a) all HFrEF patients, (b) only patients with coronary artery disease (CAD) and (c) only patients who were in sinus rhythm (SR). Model 1 is an empty model and model 2 includes age and sex. Model 3 includes the previous model with systolic blood pressure, serum creatinine and NYHA class. Model 4 includes age, sex, NYHA class, systolic blood pressure, serum creatinine, smoking status, BMI, duration of heart failure, haemoglobin, COPD and diabetes status. Pooled SMRs estimated from 5 trials with their 95% CI were reported SR(model4) SR(model3) SR(model2) SR(model1) CAD(model4) CAD(model3) CAD(model2) CAD(model1) All(model4) All(model3) All(model2) All(model1) 1.09(1.02, 1.15) 1.03(0.97, 1.09) 1.02(0.96, 1.09) 0.63(0.59, 0.67) 0.92(0.86, 0.98) 0.84(0.79, 0.89) 0.76(0.71, 0.81) 0.4(0.38, 0.43) 1.04(0.98, 1.11) 1.01(0.95, 1.08) 0.97(0.92, 1.03) 0.52(0.49, 0.56) 0 0.2 0.4 0.6 0.8 1 1.2 1.4 All-cause mortality: pooled SMRs and 95% CI Lower risk in trials <--- ---> Higher risk in trials
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