2.2 Eligibility for HFrEF trials 65 Figure 1. Ranked eligibility criteria in HFrEF trials (n=163). Value in bracket indicate percentage. Anaemia consists of iron-deficiency anaemia and haemoglobin and ferritin thresholds. Renal disease consists of serum creatinine, estimated glomerular filtration rate, chronic or end-stage renal disease. Optimal therapy refers to required background therapy, whether medication or devices that are considered optimal standard of care at the time of the study. ACEI, angiotensin- converting enzyme inhibitor; ACS, acute coronary syndrome; AF, atrial fibrillation; ARB, angiotensin-II receptor blocker; BMI, body mass index; BNP, brain natriuretic peptides; CABG, coronary artery bypass graft; CV, cardiovascular; IV, intravenous; LBBB, left bundle branch block, LVEDD, left ventricle end diastolic diameter; LVEF, left ventricular ejection fraction; MRA, mineralocorticoid receptor antagonist; NYHA, New York Heart Association functional class; PAH, pulmonary artery hypertension; PCI, percutaneous coronary intervention; RBBB, right bundle branch block;
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