TABLE OF CONTENTS Chapter 1 General Introduction 7 Chapter 2 Comparing heart failure trial and registry populations Chapter 2.1 Generalizability of randomized controlled trials in heart failure with reduced ejection fraction 13 Chapter 2.2 Eligibility of Asian and European registry populations for phase III randomized trials in heart failure with reduced ejection fraction 53 Chapter 3 Age, sex and racial/ ethnic representation in the design of trials for heart failure Chapter 3.1 Sex differences in the generalizability of randomized controlled trials in heart failure with reduced ejection fraction: large-scale analysis of five trials and two registries 83 Chapter 3.2 Incidence of heart failure hospitalizations across ethnic groups in Malaysia: a ten-year population-based analysis from 2007 to 2016 117 Chapter 3.3 Trends for readmission and mortality after heart failure hospitalization in Malaysia, 2007 to 2016 155 Chapter 4 General Discussion 191 Appendices Summary Nederlandse samenvatting Ringkasan dalam Bahasa Melayu Acknowledgements About the author List of publications 209
RkJQdWJsaXNoZXIy MjY0ODMw