2.2 Eligibility for HFrEF trials 69 Figure 4. Cumulative eligibility for theoretical heart failure trials per addition of eligibility criteria stratifying by (A) LVEF < 40% & NYHA II, III & IV; (B) LVEF <40% & NYHA II & III; (C) LVEF ≤35% & NYHA II, III & IV; (B) LVEF ≤35% & NYHA II & III. 0.17 0.19 0.19 0.20 0.21 0.24 0.29 0.50 0.76 0.91 0.18 0.19 0.20 0.21 0.22 0.25 0.30 0.52 0.80 0.91 0.0 0.2 0.4 0.6 0.8 1.0 A NYHA II, III & IV NYHA II & III LVEF ≤40% LVEF ≤ 35% Eligibility criteria B 0.15 0.17 0.17 0.18 0.19 0.21 0.26 0.44 0.67 0.80 0.16 0.17 0.18 0.19 0.20 0.22 0.26 0.46 0.71 0.80 0.0 0.2 0.4 0.6 0.8 1.0 + K <5.5mmol/L + Hb >10g/dL + eGFR>30ml/min/1.73m2 + No stroke + No COPD /cancer + No device + No MI/ PCI/CABG + ACEI/ ARB + BB + NYHA II & III Age 18- 80 years + K <5.5mmol/L + Hb >10g/dL + eGFR>30ml/min/1.73m2 + No stroke + No COPD /cancer + No device + No MI/ PCI/CABG + ACEI/ ARB + BB + NYHA II, III & IV Age 18- 80 years D C
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