2.2 Eligibility for HFrEF trials 81 Supplementary figure 3. Cumulative eligibility for theoretical heart failure trials per addition of eligibility criteria comparing between double (any dose ACEI/ARB +BB) and triple therapy (any dose ACEI/ARB +BB +MRA) Double background therapy Triple background therapy Eligibility criteria 0.18 0.19 0.20 0.21 0.22 0.25 0.30 0.52 0.80 0.91 0.0 0.2 0.4 0.6 0.8 1.0 0.09 0.10 0.10 0.11 0.11 0.16 0.19 0.32 0.80 0.91 0.0 0.2 0.4 0.6 0.8 1.0 + K <5.5mmol/L + Hb >10g/dL + eGFR>30ml/min/1.73m2 + No stroke + No cancer / COPD + No device + No MI/ PCI/ CABG + ACEI/ ARB + BB (-/+) MRA + NYHA II, III & IV Age 18- 80 years 0
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