3.1 Sex differences in generalizability of HFrEF trials 89 populations of RCT-eligible (47.0% and 56.1%) and RCT-ineligible patients (43.0% and 48.6%) for females and males respectively. Although females in all three groups had a higher LVEF compared to males, the proportion of patients in NYHA functional class III/IV was also highest in females compared to males in all groups (46.5% vs 36.4%; 48.1% vs 42.9%; 46.6% vs 42.6%; in the RCT, RCT-eligible and RCT-ineligible groups, respectively). Figure 1. Flowchart of the selection of studied populations from available datasets and the respective proportion of males and females
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