3.1 Sex differences in generalizability of HFrEF trials 91 Table 1 (continued). Baseline characteristics compared between RCT populations, RCT-eligible registry population, and RCT-ineligible registry population, stratified by sex. RCT RCT-eligible registry RCT-ineligible registry Females Males p-valueb Females Males p-valueb Females Males pvalueb NYHA functional class *** *** *** I 0.0% 0.1% 0.0% 0.0% 17.9% 22.9% II 53.5% 63.5% 51.9% 57.1% 35.4% 34.5% III 45.8% 35.7% 43.5% 39.4% 38.5% 36.2% IV 0.7% 0.7% 4.6% 3.5% 8.2% 6.4% NYHA functional class III/IV 46.5% 36.4% *** 48.1% 42.9% *** 46.6% 42.6% *** Comorbidities % Hypertension 72.0% 67.0% *** 59.1% 54.7% *** 56.6% 54.7% * Diabetes mellitus 34.7% 33.5% 25.8% 27.8% *** 25.7% 27.8% ** CAD 79.3% 87.8% *** 49.0%a 48.6% 48.1%a 57.4% *** Valvular heart disease 14.9% 11.0% *** 24.2% 20.2% *** 26.5% 25.0% * Stroke or TIA 9.1% 9.3% 14.3%a 14.0%a 16.6%a 18.1%a * Atrial fibrillation/flu tter 9.7% 8.9% 42.2% 46.7% *** 47.8% 54.9% *** COPD 6.9% 9.3% *** 21.3% 18.6% *** 22.1% 20.9% *
RkJQdWJsaXNoZXIy MjY0ODMw