3.1 Sex differences in generalizability of HFrEF trials 95 Table 2. Unadjusted outcome rates between males and females, stratified by RCT population, RCT-eligible registry population, and RCTineligible population at one-year. RCT RCT-eligible RCT-ineligible Female s Males Proportion Difference (99%CI) Females Males Proportion Difference (99%CI) Females Males Proportion Difference (99%CI) All-cause mortality 5.6% (201) 6.9% (910) -1.4% (-2.5%, - 0.3%) ** 14.0% (1005) 10.7% (1671) 3.4% (2.1%, 4.6%) *** 28.6% (1468) 24.6% (3017) 4.0% (2.1%, 5.9%) *** CV-cause mortality 5.0% (183) 6.2% (822) -1.2% (-2.3%, - 0.1%) ** 10.6% (761) 8.1% (1267) 2.5% (1.5%, 3.6%) *** 20.2% (1038) 17.0% (2078) 3.3% (1.6%, 4.9%) *** First HF Hospitaliza tion 8.4% (308) 7.8% (1034) 0.6% (-0.7%, 1.9%) 23.2% (1660) 24.8% (3885) -1.6% (-3.2%, 0.0%) ** 23.7% (1214) 25.3% (3097) -1.6% (-3.5%, 0.2%) * *p<0.05, **p<0.01, ***p<0.001 based on ꭓ2 -test, 99% CI calculated
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